Harmful effect of chemical compounds used in agriculture on the human health

Résumé

Recently, it was observed an increased usage of microtubules-depolymerizing agents, such as pesticides and anti-fungal or antiparasitic compounds to help the production of the agriculture products. All these chemical compounds are used in agriculture and have a destroying effect on human health, leading on the appearance of neurodegenerative diseases. For this reason, many researches are focused on the understanding in detail the correlation between the general mechanism of action for pesticides and microtubules deploymerization process which is present in the human cell. In this paper, we present the analysis of the mechanism involved in depolymerizing of the microtubules structure through molecular dynamic simulations. This mechanism is time dependent and contributes to the deterioration of the neuronal transport carried-out by the kinesin and microtubules, leading to a miss carriage of the Ca+ ions to the nerve synapse. Aided by molecular dynamics simulations, the health monitoring of the microtubules is carried out by measuring the evolution of some mechanical parameters which characterize the integrity of the microtubules and their capacity to be transporters for the neuronal signs.