Effect of 5,4'-dihydroxy-3,6,7,8-tetramethoxyflavone and 5,3'-dihydroxy-3,6,7,8,4'-pentamethoxyflavone on mitochondrial function in living K562 and K562/adr cancer cells

Auteur/ices

  • Jittraporn Chaipratet Faculty of Associated Medical Sciences, Chiang Mai University
  • Montree Tungjai Faculty of Associated Medical Sciences, Chiang Mai University

Mots-clés :

5,4′-dihydroxy-3,6,7,8-tetramethoxyflavone (WP279), 5,3′-dihydroxy-3,6,7,8,4′-pentamethoxyflavone (WP283), mitochondrial membrane potential, spectrofluorescence technique

Résumé

In the previously study we reported speciation of methoxyflavone including 5,4'-dihydroxy-3,6,7,8-tetramethoxyflavone (WP279) and 5,3'-dihydroxy-3,6,7,8,4'-penta methoxyflavone (WP283) in a physiological solution and their anticancer property. The objective of this study was to determine the effect of 5,4'-dihydroxy-3,6,7,8-tetramethoxyflavone and 5,3'-dihydroxy-3,6,7,8,4'-pentamethoxyflavone on mitochondrial membrane potential in drugsensitive, K562 and drug-resistance, K562/adr cancer cell lines by using spectrofluorescence technique. The result shows that WP279 and WP283 slightly increased the mitochondrial membrane potential in K562 and K562/adr due to the concentration.

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Publiée

2011-03-02

Numéro

No 8 (2011)

Rubrique

Articles

Comment citer

1.
Effect of 5,4’-dihydroxy-3,6,7,8-tetramethoxyflavone and 5,3’-dihydroxy-3,6,7,8,4’-pentamethoxyflavone on mitochondrial function in living K562 and K562/adr cancer cells. ifrb [Internet]. 2 mars 2011 [cité 2 nov. 2026];(8):8-12. Disponible sur: https://ojs.ugal.ro/index.php/IFRB/article/view/3367